Christoffer Mattsson Langseth

Computational biologist

Spatial omics

Neuroinflammation

Mitochondria & metabolism

Exercise physiology

Welcome! I am a postdoctoral researcher at Karolinska Institutet, where I combine advanced spatial omics technologies with questions in neuroinflammation, mitochondrial biology, and metabolic adaptation. My work aims to understand how cellular energy states shape disease trajectories—and how interventions such as endurance exercise can modulate CNS resilience.

My research spans several interconnected areas:

• Spatially resolved omics
  High-resolution in situ technologies (10x Xenium, ISS, HybISS) to map cellular states, tissue remodeling, and inflammatory niches across space and time.

• Mitochondrial dysfunction & bioenergetic stress
  Understanding how metabolic rewiring, lactate flux, and mitochondrial impairment contribute to lesion development, neurodegeneration, and adaptive responses.

• Neuroinflammation & neuron–glia interactions
  Integrating large-scale spatial transcriptomics with single-cell RNA-seq and proteomics to dissect immune infiltration, glial activation, and tissue pathology in multiple sclerosis (MS) and experimental models (EAE).

• Endurance exercise & CNS resilience
  Exploring how systemic metabolic stressors—such as endurance training—reshape CNS cell states, immune tone, mitochondrial function, and susceptibility to inflammatory injury.

I aim to bridge experimental neuroimmunology, systems metabolism, and computational spatial biology to develop a mechanistic framework for understanding CNS resilience and vulnerability.

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More about my work

• Research vision and long-term strategy:
  https://github.com/christoffermattssonlangseth/research-vision

• GitHub profile (code, pipelines, figures):
  https://github.com/christoffermattssonlangseth